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Preheat the oven to 375°F (190°C) and line a baking sheet with parchment paper. Set aside.
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In a large bowl, stir together flour, sugar, baking powder, baking soda, and salt in a large bowl.
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Rub the butter into the flour mixture with a pastry blender or your fingers until the mixture resembles coarse breadcrumbs. Toss in the blackberries.
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Combine the buttermilk and vanilla extract in a small jug, then pour into the flour mixture. Stir gently until the dough just comes together.
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Turn the dough onto the prepared baking sheet and press into a circle that is 1-inch (3 cm) thick and about 7 inches (18 cm) in diameter.
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Cut the circle into 8 wedges and push apart so they have room to expand.
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Brush the tops with egg wash and bake for 20-22 minutes, or until the tops are golden brown and the scones feel firm when lightly pressed. Let cool completely on a wire rack.